Abstract: The feed cabin of the five-hundred-meter aperture spherical radio telescope operates at an altitude of 140 meters, which is sensitive to wind load. Excessive wind-induced response may affect the normal operation of the feed cabin. The aerodynamic characteristics of the feed cabin structure are studied by CFD numerical simulation. The research results confirm that the surface bulge has a great influence on the aerodynamic characteristics of the feed cabin structure. According to the research results, the wind direction with the largest aerodynamic coefficient is 240 degree and the wind direction of potential vortex-induced vibration is 180 degree. Then the parametric analysis is presented for the 180 degree wind direction. The vortex shedding frequency and Strouhal number are calculated under different wind speeds. Besides, a complete refined simulation model of the feed cabin-cable-tower coupled system is established. The results of modal analysis show that the fundamental frequency of the structure is very low and the modes are dense. Multiple modes of the structure can be successively excited in normal wind speed. The wind response analysis is carried out for 240 degree wind direction with the largest aerodynamic coefficient. The dynamic responses of the feed cabin-cable-tower coupled system are calculated under the working wind speed and the design wind speed. The results show that the displacement of the feed cabin under the working wind speed will not affect its working accuracy, and the whole structure is in a safe level under the design wind speed. When the secondary fine-tuning platform is turned on and off, the maximum working wind speed can reach 9.3 m/s and 4.3 m/s, respectively.